This implementation playbook provides practical guidance for improving performance on the Depression Screening and Follow-Up measure. It explains how screening results and follow-up care move across clinical teams, health plans, intermediaries, behavioral health providers, pharmacies, and data-exchange partners. The playbook identifies common barriers, including inconsistent EHR configuration, incomplete coding, limited visibility into external follow-up care, claims limitations, manual submission processes, and discrepancies between practice and health plan data. It outlines recommended workflows for capturing structured screening data, documenting qualifying follow-up services, selecting appropriate codes, and submitting supplemental data to health plans. The resource also includes implementation considerations for several EHR platforms, health plan-specific support resources, and recommendations for more standardized and automated data exchange. Practices, health plans, and technology partners can use the playbook to reduce administrative burden, improve data accuracy, strengthen care coordination, and ensure completed depression screening and follow-up activities are reflected in quality reporting.