This toolkit provides guidance and practical resources for implementing health-related social needs screening in healthcare settings. It can help practices determine which needs to screen for, select or adapt screening questions, prepare staff, integrate screening into clinical workflows, and develop processes for responding to identified needs. Practices can use the toolkit to support consistent screening, patient-centered conversations, documentation, referrals, and follow-up. Screening should be paired with clear response protocols, appropriate staff training, privacy protections, and established connections to community resources. The Learning Center includes this toolkit among the screening resources supporting the EPT Health-Related Social Needs Screening and Linkage milestone.